Volume 12 Supplement 1

11th Annual Conference of the International Society for the Prevention of Tobacco Induced Diseases (ISPTID)

Open Access

Acute effect of an e-cigarette with and without nicotine on lung function

  • Anastasios Palamidas1,
  • Sophia Antiopi Gennimata1,
  • Georgios Kaltsakas1,
  • Stamatoula Tsikrika1,
  • Sophia Vakali1,
  • Christina Gratziou1 and
  • Nikolaos Koulouris1
Tobacco Induced Diseases201412(Suppl 1):A34

DOI: 10.1186/1617-9625-12-S1-A34

Published: 6 June 2014

Background

E-cig is an electrical device that vaporizes propylene or polyethylene glycol-based liquid solution into an aerosol mist containing different concentration of nicotine. Our preliminary study showed an increase in Raw, a concomitant decrease in sGaw and an increase in slope of phase III in a limited number of subjects immediately after smoking a single e–cig containing nicotine.

Materials and methods

We extended our protocol in a larger group of never smokers and in smokers. We implemented the same protocol with a nicotine free e-cig in a group of never smokers. We studied 60 subjects before and after smoking an e-cig containing 11mg nicotine (Group A). Group A: 9 never smokers and 51 smokers (24 had no overt airways disease, 11 asthma, 16 COPD). Another group of 10 never smokers used a nicotine free e-cig (Group B). Lung function assessed pre and post e-cig use including lung volumes, airway resistance (Raw), specific airway conductance (sGaw) and the slope of phase III. The same brand of e-cig used in both groups, with 11 and 0mg of nicotine.

Results

Group A: a significant increase in Raw was shown in smokers and in never smokers (0.284±0.13-0.308±0.14; p= 0.033, 0.246±0.07-0.292±0.05; p=0.006) with significant decrease in sGaw (1.197±0.50-1.060±0.42; p= 0.009, 1.313±0.22-1.109±0.18; p= 0.043). Increased slope in phase III was shown only in asthmatic patients (p=0.008). Group B: increase in Raw (0.247±0.03-0.333±0.08; p=0.005) and a decrease in sGaw (1.213±0.29-0.944±0.18; p=0.009) noted.

Conclusions

The present study supports our preliminary results showing increased Raw and a concomitant decrease in sGaw. These changes might be due to the vaporizing liquid but not to the inhaled nicotine per se.

Authors’ Affiliations

(1)
Research unit for Tobacco Control, 1st Respiratory Department, University of Athens, Medical School, Sotiria Hospital

Copyright

© Palamidas et al; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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