From: Genetics of Tobacco Use
First Author, Year | Population, Sample size | Gene | Statistically Significant (p < 0.05) Results |
---|---|---|---|
Erblich 2004 | USA N = 108 smokers | SLC6A3-9/*avs. 10/10 | SLC6A3-9/* increases number of cigarettes/day |
 |  | DRD2 A1/*avs. A2/A2 | SLC6A3-9/* & DRD2 A1/* exhibit greater cigarette craving reactions |
 |  |  | Additive interaction of both gene variants |
Vandenbergh 2002 | USA N = 595 | SLC6A3-10/10, 9/10, 9/9 | SLC6A3-9/* predicts increased smokingb |
Yoshida 2001 | Japan N = 332 | DRD2 A1/A1, A1/A2, A2/A2 | A2 predicts increased smoking |
Wu 2000 | USA N = 140 lung cancer cases and 222 controls | DRD2 A1/A1, A1/A2, A2/A2 | DRD2 predicts increased smoking, pack-years and number of cigarettes/day |
 |  | DRD2 B1/B1, B1/B2, B2/B2 | A1 & case status interact to increase risk of family history of smoking-related cancer |
Beirut 2000 | USA N = 970 Alcoholism study subjects and their first-degree relatives | DRD2 A1/* vs. A2/A2 | No significant differences by genotype |
Lerman 1999 | USA N = 522 | DRD2 A1/* vs. A2/A2 | SLC6A3-9/* predicts non-smoking, older age at initiation of smoking, and longer previous quit attempts |
 |  | SLC6A3-9/* vs. */* | DRD2-A1/* predicts smoking only through interaction with SLC6A3 |
Sabol 1999 | USA N = 1,107 | SLC6A3-9/* vs. */* | SLC6A3-9/* predicts smoking cessation & low novelty-seeking |
 |  | DRD2 A1/* vs. A2/A2 |  |
Spitz 1998 | USA N = 283 | DRD2 A1/* vs. A2/A2 | DRD2 A1/* or B1/* predict increased smoking, younger age at initiation & fewer attempts to quit |
 |  | DRD2 B1/* vs. B2/B2 |  |
Comings 1996 | USA N = 1026 (479 of which are from literature) | DRD2 A1/* vs. */* | DRD2 A1/* predicts smoking |
Noble 1994 | USA N = 354 | DRD2 A1/* vs. A2/A2 | DRD2 A1/* predicts increased smoking |
Smith 1992 | USA N = 232 | DRD2 A1/* vs. A2/A2 | DRD2 A1/* or B1/* predict increased substance use |
 |  | DRD2 B1/* vs. B2/B2 |  |