Table 4 How NRT is related to different symptoms N = 625

Craving

36% (88/242)

53% (98/185)

42% (83/198)

2.0 (1.3–2.9)*

1,3 (0.9–1.9)

Irritability

48% (117/242)

60% (111/185)

47% (94/198)

1.6 (1.1–2.4)*

1.0 (0.7–1.4)

Apprehension/anxiety

51% (123/242)

57% (106/185)

45% (89/198)

1.3 (0.9–1.9)

0.8 (0.5–1.2)

Restlessness

56% (136/242)

63% (116/185)

61% (120/198)

1.3 (0.9–1.9)

1.2 (0.8–1.8)

Difficulties concentrating

44% (107/242)

55% (101/185)

46% (92/198)

1.5 (1.0–2.2)*

1.1 (0.8–1.6)

Depression/depressed mood

43% (103/242)

47% (87/185)

41% (82/198)

1.2 (0.8–1.8)

1.0 (0.7–1.4)

Headache

38% (91/242)

43% (80/185)

38% (76/198)

1.3 (0.9–1.9)

1.0 (0.7–1.5)

Insomnia

49% (118/242)

54% (99/185)

56% (111/198)

1.2 (0.8–1.8)

1.3 (0.9–2.0)

Sleepiness/drowsiness

39% (94/242)

41% (76/185)

39% (78/198)

1.1 (0.7–1.6)

1.0 (0.7–1.5)

Nightmares

28% (67/242)

27% (50/185)

32% (64/198)

1.0 (0.6–1.5)

1.2 (0.8–1.9)

Dizziness

35% (85/242)

35% (64185)

32% (64/198)

1.0 (0.7–1.5)

0.9 (0.6–1.3)

Mouth ulcers

15% (36/242)

22% (41/185)

24% (47/198)

1.6 (1.0–2.7)*

1.8 (1.1–2.9) *

Sweating

40% (96/242)

45% (83/185)

41% (82/198)

1.2 (0.8–1.8)

1.1 (0.7–1.6)

Muscular pain

26% (62/242)

23% (43/185)

23% (46/198)

0.9 (0.6–1.4)

0.9 (0.6–1.4)

Cramps

15% (35/242)

6% (11/185)

15% (29/198)

0.4 (0.2–0.8)*

1.0 (0.6–1.7)

Constipation

26% (62/242)

29% (53/185)

35% (69/198)

1.2 (0.8–1.8)

1.6 (1.0–2.3) *

Other stomach trouble

21% (52/242)

25% (47/185)

29% (58/198)

1.2 (0.8–1.9)

1.5 (1.0–2.3) *