Table 2 Geometric mean thymine glycol (d(TgpA)), formamide (d(PfpA)) and 8-oxo-7,8-dihydroguanine (dGh) lesions (fmol/μg) by week, unadjusted and adjusted for age, gender, and treatment condition
From: Reduction in oxidatively generated DNA damage following smoking cessation
Sample (N) | % abstinent | Cigarette per week (SEM) | d(TgpA) fmol/μg (SEM) | d(PfpA) fmol/μg (SEM) | dGhfmol/μg (SEM) | |||
|---|---|---|---|---|---|---|---|---|
Unadj | Adj | Unadj | Adj | Unadj | Adj | |||
TQD - 4 weeks [baseline] (N = 19) | 0 | 126 (7.5) | 0.89 (1.15) | 1.06 (0.15) | 1.77 (1.13) | 1.93 (0.20) | 31.70 (1.12) | 33.15 (2.49) |
TQD [week 0] (N = 19) | 68.4 | 85 (8.7) | 0.55 (1.19) | 0.71 (0.10) | 1.51 (1.09) | 1.55 (0.12) | 21.97 (1.07) | 21.48 (1.68) |
TQD + 4 weeks [week 4] (N = 13) | 100 | 0 | 0.57 (1.17) | 0.64 (0.09) | 1.07 (1.14) | 1.12 (0.17) | 16.40 (1.11) | 15.76 (1.65) |
TQD +11 [week 11] (N = 10) | 100 | 0 | 0.81 (1.18) | 0.91 (0.13) | 1.25 (1.13) | 1.23 (0.14) | 15.56 (1.15) | 15.43 (2.60) |