Table 1 Up- and down- regulated genes (>2.0 fold change) in alveolar macrophages of ‘healthy smokers’

PLA2G7

phospholipase A2, group VII

up

Woodruff et al. [68], Graff et al. [69], Philibert et al. [70]

SPP1

secreted phosphoprotein 1 (osteopontin)

up

Woodruff et al. [68], Graff et al. [69]

CYP1B1

cytochrome P450, family 1, subfamily B, polypeptide 1

up

Woodruff et al. [68], Graff et al. [69], Philibert et al. [70]

ATP6VOD2

ATPase, H+ transporting, lysosomal 38 kDa, V0 subunit d2

up

Woodruff et al. [68], Graff et al. [69]

SLC7A11

solute carrier family 7, member 11 (xCT)

up

Woodruff et al. [68], Graff et al. [69]

MMP12

matrix metallopeptidase 12 (macrophage elastase)

up

Woodruff et al. [68], Graff et al. [69] Heguy et al. [71]

FABP3

fatty acid binding protein 3

up

Woodruff et al. [68], Graff et al. [69]

FLT1

fms-related tyrosine kinase 1 (VEGFR)

up

Woodruff et al. [68], Graff et al. [69], Philibert et al. [70]

A2M

alpha-2-macroglobulin

up

Woodruff et al. [68], Graff et al. [69] Heguy et al. [71]

UCHL1

ubiquitin carboxyl-terminal esterase L1

up

Woodruff et al. [68], Graff et al. [69]

S100B

S100 calcium binding protein B

up

Woodruff et al. [68], Graff et al. [69], Philibert et al. [70]

CA2

carbonic anhydrase II

up

Woodruff et al. [68], Graff et al. [69]

SLC16A6

solute carrier family 16, member 6 (monocarboxylic acidtransporter)

up

Woodruff et al. [68], Graff et al. [69]

SSBP3

single stranded DNA binding protein 3

up

Woodruff et al. [68], Graff et al. [69]

TDRD9

tudor domain containing 9

up

Woodruff et al. [68], Graff et al. [69]

C4orf18

chromosome 4 open reading frame 18 (DKFZp434L142)

up

Woodruff et al. [68], Graff et al. [69]

DNASE2B

deoxyribonuclease II beta

up

Woodruff et al. [68], Graff et al. [69]

SDC2

syndecan 2

up

Woodruff et al. [68], Graff et al. [69]

MGST1

microsomal glutathione S-transferase 1

up

Woodruff et al. [68], Graff et al. [69]

AGPAT9

1-acylglycerol-3-phosphateO-acyltransferase 9

up

Woodruff et al. [68], Graff et al. [69]

TMTSF4

transmembrane 7 superfamily member 4 (DCSTAMP)

up

Woodruff et al. [68], Graff et al. [69]

LIPA

lipase A, lysosomal acid, cholesterol esterase

up

Woodruff et al. [68], Graff et al. [69]

CSF1

Colony-stimulating factor 1

up

Heguy et al. [71], Rose et al. [72]

CCR5

Chemokine (C-C motif) receptor 5

up

Woodruff et al. [68], Graff et al. [69], Philibert et al. [70]

CXCL11

chemokine (C-X-C motif) ligand 11

down

Woodruff et al. [68], Graff et al. [69]

CXCL9

chemokine (C-X-C motif) ligand 9

down

Woodruff et al. [68], Graff et al. [69], Philibert et al. [70]

SLC19A3

solute carrier family 19 (thiamine transporter)

down

Woodruff et al. [68], Graff et al. [69]

EMR1

egf-like module containing, mucin-like, hormonereceptor-like 1 (F4/80)

down

Woodruff et al. [68], Graff et al. [69]

CXCL10

chemokine (C-X-C motif) ligand 10

down

Woodruff et al. [68], Graff et al. [69]

PDGFD

platelet derived growth factor D

down

Woodruff et al. [68], Graff et al. [69]

IGF1

insulin-like growth factor 1

down

Woodruff et al. [68], Graff et al. [69]

GBPS

guanylate binding protein 5

down

Woodruff et al. [68], Graff et al. [69]

C8B

complement component 8, beta

down

Woodruff et al. [68], Graff et al. [69]

CD69

CD69 molecule

down

Woodruff et al. [68], Graff et al. [69]

WDR69

WD repeat domain 49

down

Woodruff et al. [68], Graff et al. [69]

TNFSF10

tumor necrosis factor (ligand) superfamily, member 10 (TRAIL)

down

Woodruff et al. [68], Graff et al. [69]

IFI27

interferon, alpha-inducible protein 27 (ISG12)

down

Woodruff et al. [68], Graff et al. [69]

TRHDE

thyrotropin-releasing hormone degrading enzyme

down

Woodruff et al. [68], Graff et al. [69]

MYB

v-myb myeloblastosis viral oncogene homolog

down

Woodruff et al. [68], Graff et al. [69], Philibert et al. [70]

ARHGAP24

Rho GTPase activating protein 24

down

Woodruff et al. [68], Graff et al. [69]

TRPC6

transient receptor potential cation channel,subfamily C, member 6

down

Woodruff et al. [68], Graff et al. [69]

ITHIHS

inter-alpha (globulin) inhibitor H5

down

Woodruff et al. [68], Graff et al. [69]