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aMean value ± 1 standard deviation
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bChi square test
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cOne way analysis of variance
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dKruskal-Wallis test
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eHistory of coronary artery disease defined as either angiographically proven coronary artery disease or a hospital diagnosis of myocardial infarction, presence of atrial fibrillation, impaired left ventricular systolic function (ejection fraction <50%), significant valvular heart disease, pulmonary hypertension, or left ventricular hypertrophy. Comprehensive definitions of these conditions are in given in reference 3
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fResidual tumor at the time of referral or time interval between cancer surgery/end of chemotherapy/radiotherapy and referral <3 months
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gEstimated glomerular filtration rate
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hFEV1 loss [% predicted] = 100% - FEV1 % predicted
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iNumbers of patients with {squamous cell cancer – adenocarcinoma – other histologic subtype}
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jMedian value, with interquartile range in brackets
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kFisher’s exact test, distribution of histologic subtypes
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lOne way analysis of variance for the log transformed values