Table 1 Per cent distribution of Hp phenotypes in consecutive healthy puerperae
Rome | Penne | ||||||||
Hp phenotypes | Hp phenotypes | ||||||||
*1/*1 | *2/*1 | *2/*2 | n° | *1/*1 | *2/*1 | *2/*2 | n° | ||
Smoking | < 24 yrs(A) | 25.0 | 40.0 | 35.0 | 40 | 42.8 | 42.8 | 14.3 | 7 |
≥ 24 yrs(B) | 13.8 | 42.6 | 43.6 | 94 | 8.3 | 41.7 | 50.0 | 24 | |
Not smoking | < 24 yrs(C) | 15.8 | 44.7 | 39.5 | 38 | 18.6 | 48.6 | 32.8 | 70 |
≥ 24 yrs(D) | 14.2 | 43.4 | 44.0 | 182 | 10.4 | 45.3 | 44.3 | 212 | |
Three way contingency table analysis by a loglinear model | |||||||||
x = Hp phenotype | |||||||||
y = age | |||||||||
z = locality | |||||||||
*1/*1 vs other Hp phenotypes | *1/*1 vs *2/*2 phenotype | ||||||||
G | df | p | G | df | p | ||||
SMOKING | |||||||||
xyz interaction | 1.453 | 1 | NS | 2.241 | 1 | NS | |||
xy association | 6.399 | 2 | < 0.05 | 7.686 | 2 | < 0.02 | |||
NON-SMOKING | |||||||||
xyz interaction | 0.454 | 1 | NS | 0.662 | 1 | NS | |||
xy association | 3.275 | 2 | NS | 4.623 | 2 | NS | |||
Comparison between Hp*1/*1 with smoking habit vs other women | |||||||||
age < 24 yrs vs age ≥ 24 yrs (Rome plus Penne) | |||||||||
Chi square test of independence | df | p | |||||||
8.82 | 1 | < 0.005 | |||||||
Deviation from Hardy-Weinberg expectation | |||||||||
Rome | Penne | ||||||||
(A) | p < 0.02 | p < 0.02 (combining probabilities p < 0.005) | |||||||
(B) | p NS | p NS | |||||||
(C) | p NS | p NS | |||||||
(D) | p NS | p NS | |||||||
Hp gene frequencies | Hp*1 | Hp*2 | |||||||
Rome | 0.362 | 0.638 | |||||||
Penne | 0.356 | 0.644 | |||||||