Table 2 Impact of gene polymorphisms of enzymes participating in the metabolism of tobacco smoke products: N-acteyltransferase 2 (NAT2) and myeloperoxidase (MPO). Shown is the distribution of subjects with severe periodontitis (more than 30% of sites have attachment loss > 6 mm) versus those having no attachment loss ≥ 6 mm. NAT2 high activity: homo- or heterozygous with allele NAT2*4; MPO highly expressed variant coded by homozygous G/G subjects. Shown are crude odds ratios (95% confidence intervals, C.I.)
| Â | Â | NAT2 | MPO | ||||
|---|---|---|---|---|---|---|---|
Smoking | High activity variant | AV6 mm > 30% | AV6 mm = 0 | odds ratio | AV6 mm > 30%> | AV6 mm = 0 | odds ratio |
never | present | 22 | 132 | 1.0 (ref.) | 38 | 160 | 1.0 (ref.) |
never | no | 29 | 128 | 1.4 (0.7 – 2.6) | 13 | 100 | 0.5 (0.3 – 1.1) |
current | no | 38 | 54 | 4.2 (2.2 – 8.2) | 21 | 67 | 2.9 (1.5 – 6.0) |
current | present | 28 | 24 | 7.0 (3.3 – 15.2) | 45 | 114 | 4.0 (2.2 – 7.0) |