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Figure 1 | Tobacco Induced Diseases

Figure 1

From: Cotinine inhibits the pro-inflammatory response initiated by multiple cell surface Toll-like receptors in monocytic THP cells

Figure 1

Cotinine-induced suppression of cytokine induction on specific stimulation of TLRs. TNF secretion was monitored following stimulation with TLR specific agonists at 1μg/ml (A, Pam2CGDPKHPKSF [TLR2/1]; B, FSL [TLR2/6); C, LPS [TLR4]; and D, flagellin [TLR5]) with and without cotinine pre-incubation (10–1000 ng/ml, 2 hr). Results are presented as percentage of TLR2/1, TLR2/6, TLR4 and TLR 5 agonist alone. 100% represents (mean ± s.d.) 25568 ± 1560 ng/ml, 10347 ± 2842 ng/ml, 4671 ± 117 ng/ml and 1583 ± 176 ng/ml for Pam2CGDPKHPKSF, FSL, LPS and flagellin, respectively. */**/*** p < 0.05, 0.01 and 0.001, respectively, compared to agonist only.

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Tobacco Induced Diseases

ISSN: 1617-9625

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