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Table 2 Serum liver enzyme levels by smoking status and ND2-237 Leu/Met genotype

From: NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modifies effects of cigarette smoking on risk of elevated levels of serum liver enzyme in male Japanese health check-up examinees: a cross-sectional study

 

Smoking status

P for trend

Never- or ex-smokers

1-20 cigarettes smoked per day

>20 cigarettes smoked per day

ND2-237Leu

N = 149

N = 70

N = 32

 

AST (U/L)

24.5 (3.9)

23.2 (5.6)

46.0 (8.3)

0.071

AST (U/L)†

20.4 (7.0)

18.4 (8.2)

40.6 (10.2)

0.120

ALT (U/L)

26.7 (3.2)

24.8 (4.6)

37.9 (6.8)

0.290

ALT (U/L)†

23.8 (5.6)

21.9 (6.6)

35.5 (8.2)

0.282

GGT (U/L)

65.4 (6.3)

67.8 (9.2)

74.0 (13.6)

0.574

GGT (U/L)†

55.6 (10.8)

61.9 (12.6)

68.9 (15.8)

0.338

ND2-237Met

N = 99

N = 46

N = 25

 

AST (U/L)

24.7 (1.3)

26.3 (2.0)

26.2 (2.7)

0.521

AST (U/L)†

19.9 (2.7)

24.0 (2.7)

21.4 (3.7)

0.313

ALT (U/L)

27.9 (2.3)

33.0 (3.4)

32.8 (4.6)

0.209

ALT (U/L)†

22.2 (4.6)

31.4 (4.7)

25.8 (6.3)

0.168

GGT (U/L)

56.4 (5.1)

70.4 (7.5)

67.6 (10.2)

0.163

GGT (U/L)†

46.9 (10.5)

64.1 (10.7)

54.6 (14.3)

0.232

  1. AST; aspartate aminotransferase, ALT; alanine aminotransferase, GGT; gamma-glutamyltransferase.
  2. †AST, †ALT and †GGT levels are given as least-square means (S.E) adjusted for age, body mass index, alcohol consumption, coffee consumption, antihypertensive treatment and antidiabetic treatment.
  3. Tukey-Kramer correction for multiple comparisons was applied.