Table 3 Odds ratios (ORs) and 95% confidence intervals (CIs) for elevated levels of serum alanine aminotransferase (ALT) by ND2-237 Leu/Met genotype and smoking status
Genotype and number of cigarettes smoked daily | Frequency | OR (95% CI) | Adjusted OR†(95% CI) | |
|---|---|---|---|---|
Normal levels of serum ALT | Elevated levels of serum ALT | |||
serum ALT levels ≤ 30 U/L | serum ALT levels > 30 U/L | |||
ND2-237Leu | Â | Â | Â | Â |
0 (never- or ex-smoker) | 101 (67.8) | 48 (32.2) | 1 (reference) | 1 (reference) |
1-20 | 55 (78.6) | 15 (21.4) | 0.574 (0.295-1.117) | 0.525 (0.237-1.166) |
>20 | 27 (84.4) | 5 (15.6) | 0.390 (0.141-1.074) | 0.462 (0.143-1.492) |
| Â | Â | Â | P for trend = 0.026 | P for trend = 0.120 |
ND2-237Met | Â | Â | Â | Â |
0 (never- or ex-smoker) | 74 (74.8) | 25 (25.2) | 1 (reference) | 1 (reference) |
1-20 | 31 (67.4) | 15 (32.6) | 1.432 (0.660-3.079) | 1.826 (0.723-4.614) |
>20 | 13 (52.0) | 12 (48.0) | 2.732 (1.104-6.762)* | 3.017 (1.064-8.560)* |
| Â | Â | Â | P for trend = 0.031 | P for trend = 0.032 |
|  | serum ALT levels < 25 U/L | serum ALT levels ≥ 25 U/L |  |  |
ND2-237Leu | Â | Â | Â | Â |
0 (never- or ex-smoker) | 82 (55.0) | 67 (45.0) | 1 (reference) | 1 (reference) |
1-20 | 48 (68.6) | 22 (31.4) | 0.561 (0.308-1.021) | 0.501 (0.248-1.010) |
>20 | 26 (81.3) | 6 (18.7) | 0.282 (0.110-0.726)** | 0.255 (0.084-0.776)* |
| Â | Â | Â | P for trend = 0.003 | P for trend = 0.010 |
ND2-237Met | Â | Â | Â | Â |
0 (never- or ex-smoker) | 54 (54.6) | 45 (45.4) | 1 (reference) | 1 (reference) |
1-20 | 28 (60.9) | 18 (39.1) | 0.771 (0.378-1.572) | 0.828 (0.365-1.879) |
>20 | 10 (40.0) | 15 (60.0) | 1.800 (0.737-4.395) | 1.675 (0.633-4.435) |
| Â | Â | Â | P for trend = 0.408 | P for trend = 0.459 |