Table 4 Odds ratios (ORs) and 95% confidence intervals (CIs) for elevated levels of serum gamma-glutamyltransferase (GGT) by ND2-237 Leu/Met genotype and smoking status
Genotype and number of cigarettes smoked daily | Frequency | OR (95% CI) | Adjusted OR†(95% CI) | |
|---|---|---|---|---|
Normal levels of serum GGT | Elevated levels of serum GGT | |||
serum GGT levels < 60 U/L | serum GGT levels ≥ 60 U/L | |||
ND2-237Leu | Â | Â | Â | Â |
0 (never- or ex-smoker) | 96 (64.4) | 53 (35.6) | 1 (reference) | 1 (reference) |
1-20 | 46 (65.7) | 24 (34.3) | 0.945 (0.520-1.717) | 1.142 (0.570-2.291) |
>20 | 22 (68.7) | 10 (31.3) | 0.823 (0.363-1.868) | 1.133 (0.406-3.158) |
| Â | Â | Â | P for trend = 0.648 | P for trend = 0.772 |
ND2-237Met | Â | Â | Â | Â |
0 (never- or ex-smoker) | 68 (68.7) | 31 (31.3) | 1 (reference) | 1 (reference) |
1-20 | 26 (56.5) | 20 (43.5) | 1.687 (0.820-3.471) | 1.926 (0.852-4.351) |
>20 | 10 (40.0) | 15 (60.0) | 3.289 (1.330-8.138)* | 3.030 (1.160-7.918)* |
| Â | Â | Â | P for trend = 0.007 | P for trend = 0.019 |
|  | serum GGT levels ≤ 51 U/L | serum GGT levels > 51 U/L |  |  |
ND2-237Leu | Â | Â | Â | Â |
0 (never- or ex-smoker) | 87 (58.4) | 62 (41.6) | 1 (reference) | 1 (reference) |
1-20 | 43 (61.4) | 27 (38.6) | 0.881 (0.493-1.575) | 1.128 (0.556-2.285) |
>20 | 22 (68.7) | 10 (31.3) | 0.638 (0.282-1.442) | 0.823 (0.297-2.280) |
| Â | Â | Â | P for trend = 0.288 | P for trend = 0.855 |
ND2-237Met | Â | Â | Â | Â |
0 (never- or ex-smoker) | 62 (62.6) | 37 (37.4) | 1 (reference) | 1 (reference) |
1-20 | 22 (47.8) | 24 (52.2) | 1.828 (0.901-3.709) | 2.223 (0.994-4.969) |
>20 | 8 (32.0) | 17 (68.0) | 3.561 (1.400-9.058)** | 3.304 (1.220-8.946)* |
| Â | Â | Â | P for trend = 0.004 | P for trend = 0.009 |