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Acute effect of an e-cigarette with and without nicotine on lung function

Background

E-cig is an electrical device that vaporizes propylene or polyethylene glycol-based liquid solution into an aerosol mist containing different concentration of nicotine. Our preliminary study showed an increase in Raw, a concomitant decrease in sGaw and an increase in slope of phase III in a limited number of subjects immediately after smoking a single e–cig containing nicotine.

Materials and methods

We extended our protocol in a larger group of never smokers and in smokers. We implemented the same protocol with a nicotine free e-cig in a group of never smokers. We studied 60 subjects before and after smoking an e-cig containing 11mg nicotine (Group A). Group A: 9 never smokers and 51 smokers (24 had no overt airways disease, 11 asthma, 16 COPD). Another group of 10 never smokers used a nicotine free e-cig (Group B). Lung function assessed pre and post e-cig use including lung volumes, airway resistance (Raw), specific airway conductance (sGaw) and the slope of phase III. The same brand of e-cig used in both groups, with 11 and 0mg of nicotine.

Results

Group A: a significant increase in Raw was shown in smokers and in never smokers (0.284±0.13-0.308±0.14; p= 0.033, 0.246±0.07-0.292±0.05; p=0.006) with significant decrease in sGaw (1.197±0.50-1.060±0.42; p= 0.009, 1.313±0.22-1.109±0.18; p= 0.043). Increased slope in phase III was shown only in asthmatic patients (p=0.008). Group B: increase in Raw (0.247±0.03-0.333±0.08; p=0.005) and a decrease in sGaw (1.213±0.29-0.944±0.18; p=0.009) noted.

Conclusions

The present study supports our preliminary results showing increased Raw and a concomitant decrease in sGaw. These changes might be due to the vaporizing liquid but not to the inhaled nicotine per se.

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Correspondence to Anastasios Palamidas.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Palamidas, A., Gennimata, S.A., Kaltsakas, G. et al. Acute effect of an e-cigarette with and without nicotine on lung function. Tob. Induced Dis. 12, A34 (2014). https://doi.org/10.1186/1617-9625-12-S1-A34

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Keywords

  • Public Health
  • Asthma
  • Internal Medicine
  • Polyethylene
  • Nicotine
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