Figure 3

Examples of some potential sites where smoke exposure may alter surfactant metabolism. 1: Particulates may have a direct detergent-like effect on the surface monolayer. 2: Lipid peroxidation induced by smoke exposure. 3: Transport of surfactant-specific phospholipid and altered secretion of lamellar bodies. 4 and 5: Reduced levels of SP-A and SP-D may affect hypophase processing directly or indirectly or alter SP-D regulation of DPPC synthesis. 6: Nicotine may alter receptor expression in fetal lung.