Table 1 Epidemiologic studies of tryptophan hydroxylase (TPH) gene, serotonin transporter gene and tobacco use in human populations.
From: Genetics of Tobacco Use
First Author, Year | Population, Sample size | Gene | Statistically Significant (p < 0.05) Results |
|---|---|---|---|
Lerman 2001 | USA N = 451 | TPH A/A, A/C, C/C | A/A genotype is associated with younger age at smoking initiation |
Sullivan 2001 | USA N = 780 | TPH C218A and C779A | Allele frequency, genotype, and haplotype are associated with smoking initiation |
Lerman 2000 | USA N = 185 smokers | Serotonin Transporter 5-HTTLPR S/*avs. L/L | Interaction between genotype and neuroticism in nicotine intake, dependence and smoking motivations; neuroticism pre-dicted these behaviors among smokers with the S allele, but not among those with the L allele (no significant main effects of genotype) |
Hu 2000 | USA N = 759 | Serotonin Transporter 5-HTTLPR S/* vs. L/L | Interaction between genotype and neuroticism in smoking status, initiation and cessation; neuroticism predicted these behaviors among smokers with the S allele, but not among those with the L allele (no significant main effects of geno-type) |
Ishikawa 1999 | Japan N = 496 men | Serotonin Transporter 5-HTTLPR L/* vs. S/S | L allele predicts increased smokingband greater number of cigarettes/day |
Lerman 1998 | USA N = 498 | Serotonin Transporter 5-HTTLPR S/S, S/L, L/L | No significant differences by genotype |