|
Critical endpoint
|
Acute irritation of the eyes and upper airways
|
| |
A few (4 out of 27) individuals reacted with additional cough and slight airway obstruction
|
|
Source
|
The Health Council of the Netherlands (2007) (Wieslander et al., 2001)
|
|
Species
|
Healthy human subjects (27)
|
|
Exposure regimen
|
Propylene glycol in aviation emergency training. Exposure to artificial mist generator in short-term inhalation exposure (~1 min)
|
|
Concentrations tested (mg/m3)
|
0, 176-851
|
|
Duration of exposure
|
Average rating on 10 questions before and after 1 min propylene glycol exposure every 30 min for 4 hours
|
|
NOAEL (mg/m3)
|
-
|
|
If no NOAEL, then value for LOAEL
|
Min = 176
|
| |
Max = 851
|
| |
Mean = 309
|
|
C
alv;max
(mg/m3)
|
430-603
|
|
Source of C
alv;max
(mg/m3)
|
1 puff (50 mL [5], 70 mL [6])
|
|
MOE1-puff shisha-pen/100% transfer rate
|
Min range = 0.3-0.4 (~2.5-3x higher than in human study)
|
| |
Max range = 1.4-2
|
| |
Mean range = 0.5-0.7 (~1.4-2x higher than in human study)
|
