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Table 1 Summary MOE analysis, propylene glycol, 1-puff scenario, human study used as PoD
| Description | Selected study |
|---|---|
| Critical endpoint | Acute irritation of the eyes and upper airways |
| A few (4 out of 27) individuals reacted with additional cough and slight airway obstruction | |
| Source | The Health Council of the Netherlands (2007) (Wieslander et al., 2001) |
| Species | Healthy human subjects (27) |
| Exposure regimen | Propylene glycol in aviation emergency training. Exposure to artificial mist generator in short-term inhalation exposure (~1 min) |
| Concentrations tested (mg/m3) | 0, 176-851 |
| Duration of exposure | Average rating on 10 questions before and after 1 min propylene glycol exposure every 30 min for 4 hours |
| NOAEL (mg/m3) | - |
| If no NOAEL, then value for LOAEL | Min = 176 |
| Max = 851 | |
| Mean = 309 | |
| C alv;max (mg/m3) | 430-603 |
| Source of C alv;max (mg/m3) | 1 puff (50 mL [5], 70 mL [6]) |
| MOE1-puff shisha-pen/100% transfer rate | Min range = 0.3-0.4 (~2.5-3x higher than in human study) |
| Max range = 1.4-2 | |
| Mean range = 0.5-0.7 (~1.4-2x higher than in human study) |
