Table 2 Up- and down- regulated genes in airway epithelium of ‘healthy smokers’ reported

SAE^c/LAE^d

G6pd

glucose-6-phosphatedehydrogenase

up

Carolan et al. [78], Hackett et al. [79]

SAE/LAE

GCLC

Glutamate-cysteineligase, catalytic subunit

up

Carolan et al. [78], Hackett et al. [79], Spira et al. [82]

SAE/LAE

GPx2

Glutathioneperoxidase 2

up

Carolan et al. [78], Hackett et al. [79], Harvey et al. [80], Turetz et al. [81], Spira et al. [82], Zhang et al. [83]

SAE

GSR

Glutathionereductase

up

Carolan et al. [78], Hackett et al. [79]

SAE/LAE

ADH7

Alcoholdehydrogenase 7, mu or sigmapolypeptide

up

Carolan et al. [78], Hackett et al. [79], Harvey et al. [80], Turetz et al. [81], Spira et al. [82]

SAE/LAE

AKR1B1

aldo-keto reductasefamily 1, memberB1

up

Carolan et al. [78], Hackett et al. [79], Harvey et al. [80], Spira et al. [82], Zhang et al. [83]

SAE/LAE

AKR1C

aldo-keto reductasefamily 1, memberC

up

Carolan et al. [78], Hackett et al. [79], Harvey et al. [80], Turetz et al. [81], Spira et al. [82], Zhang et al. [83]

SAE

TXNRD1

Thioredoxinreductase 1

up

Carolan et al. [78], Hackett et al. [79], Spira et al. [82]

SAE

PGD

Phosphogluconatedehydrogenase

up

Carolan et al. [78], Hackett et al. [79]

SAE

TALDO1

transaldolase 1

up

Carolan et al. [78], Hackett et al. [79]

SAE

CYP1B1

cytochrome P450, family 1, subfamilyB, polypeptide1

up

Carolan et al. [78], Hackett et al. [79], Harvey et al. [80], Spira et al. [82], Zhang et al. [83]

SAE/LAE

CX3CLI

Chemokine(C-X3-C motif)ligand 1

down

Harvey et al. [80], Turetz et al. [81], Spira et al. [82]

SAE/LAE

ALDH3A1

Aldehydedehydrogenase 3family, memberA1

up

Harvey et al. [80], Turetz et al. [81], Spira et al. [82]

SAE/LAE

NQO1

NAD(P)Hdehydrogenase, quinone 1

up

Harvey et al. [80], Spira et al. [82], Zhang et al. [83]

LAE

SLIT

slit homolog (Drosophila)

up

Turetz et al. [81], Spira et al. [82]

SAE

UCHL1

Ubiquitincarboxylterminal, esteraseL1

down

Harvey et al. [80], Spira et al. [82]