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Table 2 Up- and down- regulated genes in airway epithelium of ‘healthy smokers’ reported

From: Are healthy smokers really healthy?

Epithelium Gene symbol Description Regulation (HSa/NSb) Reference
SAEc/LAEd G6pd glucose-6-phosphatedehydrogenase up Carolan et al. [78], Hackett et al. [79]
SAE/LAE GCLC Glutamate-cysteineligase, catalytic subunit up Carolan et al. [78], Hackett et al. [79], Spira et al. [82]
SAE/LAE GPx2 Glutathioneperoxidase 2 up Carolan et al. [78], Hackett et al. [79], Harvey et al. [80], Turetz et al. [81], Spira et al. [82], Zhang et al. [83]
SAE GSR Glutathionereductase up Carolan et al. [78], Hackett et al. [79]
SAE/LAE ADH7 Alcoholdehydrogenase 7, mu or sigmapolypeptide up Carolan et al. [78], Hackett et al. [79], Harvey et al. [80], Turetz et al. [81], Spira et al. [82]
SAE/LAE AKR1B1 aldo-keto reductasefamily 1, memberB1 up Carolan et al. [78], Hackett et al. [79], Harvey et al. [80], Spira et al. [82], Zhang et al. [83]
SAE/LAE AKR1C aldo-keto reductasefamily 1, memberC up Carolan et al. [78], Hackett et al. [79], Harvey et al. [80], Turetz et al. [81], Spira et al. [82], Zhang et al. [83]
SAE TXNRD1 Thioredoxinreductase 1 up Carolan et al. [78], Hackett et al. [79], Spira et al. [82]
SAE PGD Phosphogluconatedehydrogenase up Carolan et al. [78], Hackett et al. [79]
SAE TALDO1 transaldolase 1 up Carolan et al. [78], Hackett et al. [79]
SAE CYP1B1 cytochrome P450, family 1, subfamilyB, polypeptide1 up Carolan et al. [78], Hackett et al. [79], Harvey et al. [80], Spira et al. [82], Zhang et al. [83]
SAE/LAE CX3CLI Chemokine(C-X3-C motif)ligand 1 down Harvey et al. [80], Turetz et al. [81], Spira et al. [82]
SAE/LAE ALDH3A1 Aldehydedehydrogenase 3family, memberA1 up Harvey et al. [80], Turetz et al. [81], Spira et al. [82]
SAE/LAE NQO1 NAD(P)Hdehydrogenase, quinone 1 up Harvey et al. [80], Spira et al. [82], Zhang et al. [83]
LAE SLIT slit homolog (Drosophila) up Turetz et al. [81], Spira et al. [82]
SAE UCHL1 Ubiquitincarboxylterminal, esteraseL1 down Harvey et al. [80], Spira et al. [82]
  1. aHS: healthy smokers, bNS: nonsmokers
  2. cSAE: small airway epithelium, dLAE: large airway epithelium
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Tobacco Induced Diseases

ISSN: 1617-9625

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