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Table 2 Chemical by-products found in reference aerosol

From: Universal electronic-cigarette test: physiochemical characterization of reference e-liquid

Name GHS signal word Hazard classification CAS number S/N ratio based on TIC peak intensity
Nicotine Danger Acute Toxicity 2
Acute Aquatic Toxicity 1
Chronic Aquatic Toxicity 1
Fatal if swallowed or in contact with skin
54–11–5 115578.89
Nicotyrine Danger Skin Irritation 3
Acute Toxicity 3
Respiratory Irritation 3
487–19–4 1405.67
Propylene glycol None None 57–55–6 709.6
4–Pyridinecarboxaldehyde Warning Skin Irritation 2
Eye Irritation 2A
STOT SE 3
Combustible liquid
Harmful if swallowed
May cause respiratory irritation
872–85–5 74.1
2,4,7-trimethyl-1,8-naphthyridine NF NF 14757–44–9 59.46
1-Butanol Danger Flammable liquid 3
Acute Toxicity 4
Skin Irritation 2
Eye Damage 1
STOT SE 3
Harmful if swallowed
May cause respiratory irritation
May cause drowsiness
71–36–3 31.09
Cotinine Warning Acute Toxicity 4
Skin Irritation 2
Eye Irritation 2A
STOT SE 3
Harmful if swallowed
May cause respiratory irritation
486–56–6 27.66
5-Methyl-2-heptanol Danger Acute Toxicity. 3
Harmful if swallowed
54630–50–1 25.07
1-Methoxy butane Danger Flammable liquid 628–28–4 24.8
3-(3,4-dihydro-2H-pyrrol-5-yl) pyridine Warning Acute Toxicity 4
Skin Irritation 2
Eye Irritation 2A
STOT SE 3
Harmful if swallowed
May cause respiratory irritation
532–12–7 22.44
1-(4-pyridinylmethyl)-1H-pyrazol-5-amine Danger Acute Toxicity. 3
Harmful if swallowed
3524–31–0 18.12
2,3-dihydro-1H-inden-1-one None None 83-33-0 17.01
2-methyl 2-pentanol Warning Flammable liquid 3
Skin Irritation 2
Eye Irritation 2A
STOT SE 3
May cause respiratory irritation
590–36–3 14.99
3-Ethyl-5-hexen-3-ol Danger Skin Irritation 2
Eye Damage 1
STOT SE 3
Acute Aquatic Toxicity 3
Chronic Aquatic Toxicity 3
May cause respiratory irritation
1907–46–6 8.79
6-Methyl-1,2,3,4-tetrahydroquinoline Warning Acute Toxicity 4
Skin Irritation. 2
Eye Irritation 2A
STOT SE 3
Harmful if swallowed
May cause respiratory irritation
91–61–2 8.79
1-(p-Toluidio)-1-deoxy-beta-d-idopyranose NF NF 2870–82–8 8.75
  1. S/N ratio = Signal-to-Noise ratio
  2. TIC = Total Ion Chromatogram
  3. STOT SE = Specific Target Organ Toxicity, Single Exposure
  4. NF = Not found