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Table 2 Chemical by-products found in reference aerosol

From: Universal electronic-cigarette test: physiochemical characterization of reference e-liquid

Name

GHS signal word

Hazard classification

CAS number

S/N ratio based on TIC peak intensity

Nicotine

Danger

Acute Toxicity 2

Acute Aquatic Toxicity 1

Chronic Aquatic Toxicity 1

Fatal if swallowed or in contact with skin

54–11–5

115578.89

Nicotyrine

Danger

Skin Irritation 3

Acute Toxicity 3

Respiratory Irritation 3

487–19–4

1405.67

Propylene glycol

None

None

57–55–6

709.6

4–Pyridinecarboxaldehyde

Warning

Skin Irritation 2

Eye Irritation 2A

STOT SE 3

Combustible liquid

Harmful if swallowed

May cause respiratory irritation

872–85–5

74.1

2,4,7-trimethyl-1,8-naphthyridine

NF

NF

14757–44–9

59.46

1-Butanol

Danger

Flammable liquid 3

Acute Toxicity 4

Skin Irritation 2

Eye Damage 1

STOT SE 3

Harmful if swallowed

May cause respiratory irritation

May cause drowsiness

71–36–3

31.09

Cotinine

Warning

Acute Toxicity 4

Skin Irritation 2

Eye Irritation 2A

STOT SE 3

Harmful if swallowed

May cause respiratory irritation

486–56–6

27.66

5-Methyl-2-heptanol

Danger

Acute Toxicity. 3

Harmful if swallowed

54630–50–1

25.07

1-Methoxy butane

Danger

Flammable liquid

628–28–4

24.8

3-(3,4-dihydro-2H-pyrrol-5-yl) pyridine

Warning

Acute Toxicity 4

Skin Irritation 2

Eye Irritation 2A

STOT SE 3

Harmful if swallowed

May cause respiratory irritation

532–12–7

22.44

1-(4-pyridinylmethyl)-1H-pyrazol-5-amine

Danger

Acute Toxicity. 3

Harmful if swallowed

3524–31–0

18.12

2,3-dihydro-1H-inden-1-one

None

None

83-33-0

17.01

2-methyl 2-pentanol

Warning

Flammable liquid 3

Skin Irritation 2

Eye Irritation 2A

STOT SE 3

May cause respiratory irritation

590–36–3

14.99

3-Ethyl-5-hexen-3-ol

Danger

Skin Irritation 2

Eye Damage 1

STOT SE 3

Acute Aquatic Toxicity 3

Chronic Aquatic Toxicity 3

May cause respiratory irritation

1907–46–6

8.79

6-Methyl-1,2,3,4-tetrahydroquinoline

Warning

Acute Toxicity 4

Skin Irritation. 2

Eye Irritation 2A

STOT SE 3

Harmful if swallowed

May cause respiratory irritation

91–61–2

8.79

1-(p-Toluidio)-1-deoxy-beta-d-idopyranose

NF

NF

2870–82–8

8.75

  1. S/N ratio = Signal-to-Noise ratio
  2. TIC = Total Ion Chromatogram
  3. STOT SE = Specific Target Organ Toxicity, Single Exposure
  4. NF = Not found