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Table 3 Inflammatory cells and mediators in the blood and lung lavage of different animal models of COPD

From: Experimental animal models for COPD: a methodological review

Sample Parameters Animals Methods References
Blood WBC Guinea pig - Total WBC [51]
- Total WBC and Eosinophils in blood [50, 53]
Mediators & Cytokines Rat - TNF-α, IL-8, IL-10 [2]
Guinea pig - IL-8 [50, 52, 53]
- MDA [50, 51, 53]
Lavage WBC Mice - - Total cell and Macrophages, lymphocytes, neutrophils [29, 30, 32, 34, 77, 136, 137]
- Macrophages and neutrophils (Cells) [33, 64]
Rat - Total leukocytes, macrophage, neutrophils and lymphocyte [39, 41, 42]
-dfd - Total cell and neutrophils in lung lavage [81]
Guinea pig - Total WBC, eosinophils and neutrophils in lung lavage [52]
Mediators & Cytokines Mice - IL-8, TNF- α, IFN- γ [118]
- KC, TNF- α, MIP-2, MIP-1α, MCP-1
- TNF- α
- IL-12, IL-4, CXCL-10, CCL-22
[22]
[32]
[79, 80]
Rat - TNF-α, IL-8, IL-10 [2]
- Total protein [81]
- Total protein, TNF-α [121]
- Total protein, IL-6, IL-1β, TNF- α [98]
Guinea pig - IL-8 [52]
  1. WBC white blood cell, TNF-α tumor necrosis factor alpha, ILs (IL-1β, IL-4, IL- 6, IL-8, IL-10, IL-12) interleukin-1β, 4,6,8,10,12, MDA malondialdehyde, IFN-γ interferon gamma, KC keratinocyte chemoattractant, MIPs (MIP-2 and MIP-1α) macrophage inflammatory proteins, MCP-1 monocyte chemoattractant protein-1
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