Experimental animal models for COPD: a methodological review

Table 3 Inflammatory cells and mediators in the blood and lung lavage of different animal models of COPD

Sample	Parameters	Animals	Methods	References
Blood	WBC	Guinea pig	- Total WBC	[51]
	WBC	Guinea pig	- Total WBC and Eosinophils in blood	[50, 53]
	Mediators & Cytokines	Rat	- TNF-α, IL-8, IL-10	[2]
		Guinea pig	- IL-8	[50, 52, 53]
		Guinea pig	- MDA	[50, 51, 53]
Lavage	WBC	Mice	- - Total cell and Macrophages, lymphocytes, neutrophils	[29, 30, 32, 34, 77, 136, 137]
		Mice	- Macrophages and neutrophils (Cells)	[33, 64]
		Rat	- Total leukocytes, macrophage, neutrophils and lymphocyte	[39, 41, 42]
		Rat	-dfd - Total cell and neutrophils in lung lavage	[81]
		Guinea pig	- Total WBC, eosinophils and neutrophils in lung lavage	[52]
	Mediators & Cytokines	Mice	- IL-8, TNF- α, IFN- γ	[118]
		Mice	- KC, TNF- α, MIP-2, MIP-1α, MCP-1 - TNF- α - IL-12, IL-4, CXCL-10, CCL-22	[22] [32] [79, 80]
		Rat	- TNF-α, IL-8, IL-10	[2]
			- Total protein	[81]
			- Total protein, TNF-α	[121]
			- Total protein, IL-6, IL-1β, TNF- α	[98]
		Guinea pig	- IL-8	[52]

WBC white blood cell, TNF-α tumor necrosis factor alpha, ILs (IL-1β, IL-4, IL- 6, IL-8, IL-10, IL-12) interleukin-1β, 4,6,8,10,12, MDA malondialdehyde, IFN-γ interferon gamma, KC keratinocyte chemoattractant, MIPs (MIP-2 and MIP-1α) macrophage inflammatory proteins, MCP-1 monocyte chemoattractant protein-1

ISSN: 1617-9625