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Table 3 Inflammatory cells and mediators in the blood and lung lavage of different animal models of COPD

From: Experimental animal models for COPD: a methodological review

Sample

Parameters

Animals

Methods

References

Blood

WBC

Guinea pig

- Total WBC

[51]

- Total WBC and Eosinophils in blood

[50, 53]

Mediators & Cytokines

Rat

- TNF-α, IL-8, IL-10

[2]

Guinea pig

- IL-8

[50, 52, 53]

- MDA

[50, 51, 53]

Lavage

WBC

Mice

- - Total cell and Macrophages, lymphocytes, neutrophils

[29, 30, 32, 34, 77, 136, 137]

- Macrophages and neutrophils (Cells)

[33, 64]

Rat

- Total leukocytes, macrophage, neutrophils and lymphocyte

[39, 41, 42]

-dfd - Total cell and neutrophils in lung lavage

[81]

Guinea pig

- Total WBC, eosinophils and neutrophils in lung lavage

[52]

Mediators & Cytokines

Mice

- IL-8, TNF- α, IFN- γ

[118]

- KC, TNF- α, MIP-2, MIP-1α, MCP-1

- TNF- α

- IL-12, IL-4, CXCL-10, CCL-22

[22]

[32]

[79, 80]

Rat

- TNF-α, IL-8, IL-10

[2]

- Total protein

[81]

- Total protein, TNF-α

[121]

- Total protein, IL-6, IL-1β, TNF- α

[98]

Guinea pig

- IL-8

[52]

  1. WBC white blood cell, TNF-α tumor necrosis factor alpha, ILs (IL-1β, IL-4, IL- 6, IL-8, IL-10, IL-12) interleukin-1β, 4,6,8,10,12, MDA malondialdehyde, IFN-γ interferon gamma, KC keratinocyte chemoattractant, MIPs (MIP-2 and MIP-1α) macrophage inflammatory proteins, MCP-1 monocyte chemoattractant protein-1