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Fig. 3 | Tobacco Induced Diseases

Fig. 3

From: Tumor necrosis factor-like weak inducer of apoptosis regulates quadriceps muscle atrophy and fiber-type alteration in a rat model of chronic obstructive pulmonary disease

Fig. 3

Correlation of TWEAK expression with quadriceps weight and fiber type. Immunohistochemical staining of TWEAK expression in the quadriceps muscle of a control and b COPD model rats. Markedly increased TWEAK expression was observed in the COPD group. TWEAK was concentrated to the membrane of the skeletal muscle cells (brown stain, black arrows; magnification, ×100). c Western blot analysis of TWEAK expression. Lanes 1–3 represent the control group and lanes 4–9 represent the COPD group. Levels of TWEAK expression were significant higher in COPD samples. n = 6, *P < 0.05,versus the control group. d Correlation between TWEAK expression and quadriceps muscle weight. e Correlation between TWEAK expression and type I fiber proportion. f Correlation between TWEAK and type II fiber proportion. TWEAK expression was significantly proportional (* P < 0.05) to the type II fiber ratio while being significantly inversely proportional to the weight and type I fiber proportion of the quadriceps (* P < 0.05). TWEAK, tumor necrosis factor-like weak inducer of apoptosis; COPD, chronic obstructive pulmonary disease

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